Plasma concentrations after high-dose (45 mg · kg−1) rectal acetaminophen in children
نویسندگان
چکیده
منابع مشابه
Plasma and cerebrospinal fluid pharmacokinetic parameters after single-dose administration of intravenous, oral, or rectal acetaminophen.
BACKGROUND This is the first study to compare plasma and cerebrospinal fluid (CSF) pharmacokinetics of intravenous (IV), oral (PO), or rectal (PR) formulations of acetaminophen. METHODS Healthy male subjects (N = 6) were randomized to receive a single dose of IV (OFIRMEV(®) ; Cadence) 1,000 mg (15 minute infusion), PO (2 Tylenol(®) 500 mg caplets; McNeil Consumer Healthcare), or PR acetaminop...
متن کاملcomparison of high loading dose versus usual dose of rectal acetaminophen in the treatment of febrile children
background: the superiority of antipyretic efficacy of high dose rectal acetaminophen is not well established yet. objectives: the present study aimed to compare the antipyretic effectiveness of high loading dose (30 mg/kg) and standard dose (15mg/kg) of rectal acetaminophen in febrile children. patients and methods: this triple blind randomized clinical trial was conducted on 76 patients aged ...
متن کاملPlasma concentrations of clonazepam after single rectal administration.
Clonazepam was administered rectally to six children aged 1.4 to 4.7 years in a dose of 0.05 mg/kg and to five children aged 1.4 to 4.1 years in a dose of 0.1 mg/kg. Plasma concentrations indicate that it is rapidly absorbed, and it may therefore be an alternative to rectal administration of diazepam in continuing convulsions.
متن کاملEffects of Gabapentin Suspension and Rectal Acetaminophen on Postoperative Pain of Adenotonsillectomy in Children
Introduction: Adenotonsillectomy is the main treatment for symptomatic tonsillar hypertrophy with postoperative pain as the most common associated complication. The present study aimed to compare the efficacy of gabapentin with that reported for acetaminophen on the postoperative pain of adenotonsillectomy in children. Materials and Methods: In this double-blind clinic...
متن کاملThe prophylactic effect of rectal acetaminophen on postoperative pain and opioid requirements after adenotonsillectomy in children.
BACKGROUND Postoperative pain in children is common after adenotonsillectomy. Rectal acetaminophen has been used effectively for postoperative pain management in small children. The aim of this randomized double blind study was to evaluate the prophylactic effect of rectal acetaminophen on postoperative pain management and opioid requirements in children undergoing adenotonsillectomy. MATERIA...
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ژورنال
عنوان ژورنال: Canadian Journal of Anaesthesia
سال: 1995
ISSN: 0832-610X,1496-8975
DOI: 10.1007/bf03011069